Orphenadrine Citrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Orphenadrine Citrate 是一种骨骼肌松弛剂，它作用于中枢神经系统，产生肌肉松弛作用。

Orphenadrine Citrate is a skeletal muscle relaxant, it acts in the central nervous system to produce its muscle relaxant effects.(In Vitro):Orphenadrine citrate (12 μM; 24.5 h) shows neuroprotective effects on 3-NPA-induced neurotoxicity cerebellar granule cells.(In Vivo):Orphenadrine citrate (10, 20, 30 mg/kg; i.p.; once aday for 3 days) reduces 3-NPA-induced mortality in a dose-dependent manner.Orphenadrine citrate (30 mg/kg; i.p.; once aday for 3 days) shows activity to against 3-NPA-induced neuronal damage in vivo.

Orphenadrine citrate (12 μM; 24.5 h) shows neuroprotective effects on 3-NPA-induced neurotoxicity cerebellar granule cells. Cell Viability AssayCell Line:CGC cells (7-day-old Sprague Dawley rat)Concentration:6, 12, 24, 48 μM Incubation Time:24.5 h Result:Prevented cells from 3-NPA induced cellular aggregation,volume diminution and neurite fragmentation.

Orphenadrine citrate (10, 20, 30 mg/kg; i.p.; once aday for 3 days) reduces 3-NPA-induced mortality in a dose-dependent manner.Orphenadrine citrate (30 mg/kg; i.p.; once aday for 3 days) shows activity to against 3-NPA-induced neuronal damage in vivo. Animal Model:Adult male Sprague Dawley rats (275-300 g; 3-NPA toxicity model).Dosage:10, 20, 30 mg/kg Administration:Intraperitoneal injection; once aday for 3 days (30 min before 3-NPA).Result:Reduced mortality of 3-NPA toxicity rats to 10-40% (3-NPA-treated animals showed general incoordination, drowsiness and general weakness).Recovered 3-NPA-induced body weight loss, and when at 30 mg/kg reduced the level of PBR and expression of HSP27. (PBR and HSP27 are markers of neuronal damage).

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Angiogenesis

EGFR

AChR

Neurological Disease

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4682-36-4

461.5

C18H23NO·C6H8O7

>98% (HPLC)

DMSO : 100 mg/mL 216.68 mM;H2O : 10 mg/mL 21.67 mM

OC(=O)CC(O)(CC(O)=O)C(O)=O.CN(C)CCOC(C1=CC=CC=C1)C1=CC=CC=C1C

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(-20℃)

With Ice Pack

≥ 2 years