ZD-4190

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ZD-4190 是血管内皮细胞生长因子受体 2 (VEGFR2) 和表皮生长因子受体 (EGFR) 信号传导的抑制剂，用于治疗癌症。

ZD-4190 is a inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling used for the treatment of cancer.

ZD4190 exhibits cytotoxic activity against the tumor cells.

ZD4190 (100 mg/kg, p.o.) effectively delays MDA-MB-435 tumor growth in mice. In ZD4190-treated tumors, 18F-FPPRGD2 uptake has decreased significantly relative to baseline by 26.74±8.12% (p<0.05) on day 1 and by 41.19±6.63% (p<0.01) on day 3, then has returned to baseline on day 7. Tumor uptake of 18F-FLT has also decreased on both day 1 and day 3 after initiation of ZD4190 treatment. However, ZD4190 does not significantly change 18F-FDG uptake in tumors, compared with the control group. ZD4190 (50?mg/kg, p.o.) prevents outgrowth of residual tumour in a muscle model of minimal residual carcinoma. ZD4190 (12.5-100 mg/kg, p.o.) produces a dose-dependent reduction in K(trans) in PC-3 prostate tumors. At 100 mg/kg, ZD4190 reduces K(trans) in PC-3 tumors by 31% following 2 doses and by 53% following 8 doses.

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Angiogenesis

EGFR

EGFR/VEGFR2

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413599-62-9

459.28

C19H16BrFN6O2

>98% (HPLC)

DMSO:20.83 mg/mL?(45.35 mM)

COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCn1ccnn1

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(-20℃)

With Ice Pack

≥ 2 years