EBV lytic cycle inducer-1

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Epstein-Barr virus (EBV) lytic cycle inducer-1 Dp44mT (Compound C7) 是一种类似铁螯合物的化合物。Dp44mT 可与 HDAC 抑制剂 Romidespin (HY-15149) 和 SAHA 协同诱导 EBV 裂解循环。Dp44mT 在上皮癌中通过激活 ERK1/2-自噬 (autophage) 轴重新激活 EBV 裂解周期。

Epstein-Barr virus (EBV) lytic cycle inducer-1 Dp44mT (compound C7) is an iron-chelatoe-like compound. Dp44mT cooperates with HDAC inhibitor Romidespin (HY-15149) and SAHA to induce EBV lytic cycle. Dp44mT reactivates EBV lytic cycle by activating the ERK1/2-autophagy axis in epithelial cancers.

Immunofluorescence Cell Line:AGS AGS-BX1 Concentration:10 μM Incubation Time:24 h, 48 h, 72 h Result:Resulted the expression of IE proteins Zta, Rta, and early EBV lytic protein BMRF1 peaking at 24h post treatment. Immunofluorescence Cell Line:AGS-BX1 Concentration:1.25 μM, 2.5 μM Incubation Time:24 h Result:Synergistically induced the expression of the viral IE protein Zta could together with 2.5 μM of SAHA and 2.5 nM of Rmidepsin. Immunofluorescence Cell Line:HA cells Concentration: 20 μM Incubation Time:24 h Result:A significantly lower expression of Zta was observed in cells treated with the iron-precomplexed C7 when compared to cells treated with C7 with 41% higher. Cell Proliferation Assay Cell Line:AGS, AGS-BX1 Concentration:0 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM, 80 μM Incubation Time:48 h Result:Displayed significantly higher toxicity to the EBV-positive cell line AGS-BX1 than the EBV-negative counterpart.

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Microbiology/Virology

Antifection

Antifection

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394668-43-0

318.17

C14H12BrN3O

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 12.5 mg/mL (39.29 mM; 超声助溶 (<60°C)

O=C(NN=C(C1=NC=CC=C1)C)C=2C=CC=C(Br)C2

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(-20℃)

With Ice Pack

≥ 2 years