Altenuene

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Altenuene 是一种霉菌毒素，经常出现在被链格孢属真菌感染的食品和饲料中。 Altenuene 对金黄色葡萄球菌具有中等活性。 Altenuene 还对肺癌细胞系 A549、乳腺癌细胞系 MDA-MB-231 和胰腺癌细胞系 PANC-1 表现出细胞毒活性。

Altenuene is a mycotoxin, it frequently occurs in food and feed items infested by fungi of the genus Alternaria. Altenuene demonstrates moderate activity against Staphylococcus aureus. Altenuene also exhibits cytotoxic activity against lung cancer cell line A549, breast cancer cell line MDA-MB-231 and pancreatic cancer cell line PANC-1.(In Vitro):METHODS AND RESULTS:Two new polyketides, 7-hydroxy-3, 5-dimethyl-isochromen-1-one (1) and 6-hydroxy-8-methoxy-3a-methyl-3a,9b-dihydro-3H-furo[3,2-c]isochromene-2,5-dione (2), along with eleven known compounds, 5'-methoxy-6-methyl-biphenyl-3,4,3'-triol (3), 7-hydroxy-3-(2-hydroxy-propyl)-5-methyl-isochromen-1-one (4), rubralactone (5), isoAltenuene (6), Altenuene (7), dihydroAltenuenes A (8), altenusin (9), alterlactone (10), 6-O-methylnorlichexanthone (11), norlichexanthone (12), and griseoxanthone C (13) were isolated from the culture of the endolichenic fungus Ulocladium sp. Compound 2 was obtained as a racemate with an unprecedented chemical skeleton. The NMR data assignments for 3 and 4 were achieved for the first time. Compounds 1-13 were screened for their antimicrobial and radical scavenging activities. CONCLUSIONS: Compound 1 showed some antifungal activity against Candida albicans SC 5314 with IC(50) of 97.93 ± 1.12 μM. Compounds 11-13 showed strong activity against Bacillus subtilis with IC(50) in the range of 1-5 μM. Compound 12 significantly inhibited the growth of methicillin-resistant Staphylococcus aureus with IC(50) of 20.95 ± 1.56 μM. Compounds 9 and 10 showed strong radical scavenging activity in comparison with vitamin C. The plausible biosynthetic pathways for compounds 1, 2, and 4-8 were discussed.

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Microbiology/Virology

Antifection

Anti-infection

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29752-43-0

292.28

C15H16O6

>98% (HPLC)

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COc1cc(O)c2C(=O)O[C@@]3(C)C[C@H](O)[C@@H](O)C=C3c2c1

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(-20℃)

With Ice Pack

≥ 2 years