PACOCF3

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PACOCF3 (Palmityltrifluoromethylketone) 是一种选择性磷脂酶 A2 (phospholipase A2) 抑制剂，IC50 为 3.8 μM。PACOCF3 改变肾小管细胞中的 Ca2+ 信号传导。

PACOCF3 (Palmityltrifluoromet?hylketone) is a selective phospholipase A2 inhibitor with an IC50 of 3.8 μM. PACOCF3 alters Ca2+ signaling in renal tubular cells.

At a concentration of 20 μM, PACOCF3 does not change basal cytosolic free calcium concentrations ([Ca2+]i), but at concentrations of 50-250 μM PACOCF3 induced an increase in [Ca2+]i by activating extracellular Ca2+ entry which is partly suppressed by 50 μM La3+. The effect of PACOCF3 is abolished by removal of extracellular Ca2+. PACOCF3 (10 μM) enhances both the peak value and the area under the curve of the [Ca2+]i increase induced by 10 μM ATP and 1 μM bradykinin by potentiating extracellular Ca2+ influx without affecting internal Ca2+ release.

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Metabolic Enzyme/Protease

Phospholipase

Phospholipase

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141022-99-3

308.42

C17H31F3O

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 33.33 mg/mL (108.07 mM; 超声助溶 )

CCCCCCCCCCCCCCCC(=O)C(F)(F)F

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(-20℃)

With Ice Pack

≥ 2 years