ML349

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ML349 是一种有效且特异性的酰基蛋白硫酯酶 2 (APT-2) 抑制剂，Ki 为 120 nM。 ML349 也是 LYPLA2 的抑制剂，IC50 为 144 nM。

ML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kis of >10000 and 120±20 nM, respectively. ML349 is also an inhibitor of both LYPLA1 and LYPLA2 with IC50s of >3000 and 144 nM, respectivley[2]. ML348 and ML349 do not decrease cell viability, but they lead to a slight activation of AKT in NRAS mutant cells.(In Vitro):ML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kis of >10000 and 120±20 nM, respectively. ML349 is also an inhibitor of both LYPLA1 and LYPLA2 with IC50s of >3000 and 144 nM, respectivley. ML348 and ML349 do not decrease cell viability, but they lead to a slight activation of AKT in NRAS mutant cells.

ML349 is an inhibitor of acyl protein thioesterase 1 and 2 (APT-1 and APT-2) with Kisof>10000 and 120±20 nM, respectively. ML349 is also an inhibitor of both LYPLA1 and LYPLA2 with IC50s of >3000 and 144 nM, respectivley. ML348 and ML349 do not decrease cell viability, but they lead to a slight activation of AKT in NRAS mutant cells.

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Metabolic Enzyme/Protease

Phospholipase

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890819-86-0

454.56

C??H??N?O?S?

>98% (HPLC)

DMSO : 20 mg/mL (44.00 mM; Need ultrasonic)

COC1=CC=C(N2CCN(C(C3=CC4=C(C(C=CC=C5)=C5S(C4)(=O)=O)S3)=O)CC2)C=C1

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(-20℃)

With Ice Pack

≥ 2 years