Apraclonidine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Apraclonidine hydrochloride (ALO 2145) 是一种选择性 α2 和弱 α1 受体激动剂，能有效降低人眼压。Apraclonidine hydrochloride 是一种局部滴眼液，有提升眼睑的能力。

Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid.

Apraclonidine hydrochloride (ALO 2145) is more commonly used topically for glaucoma, as it penetrates the cornea and blood-brain barrier to a lesser extent and, thus, has fewer adverse systemic effects.

Apraclonidine hydrochloride (ALO 2145) is effective in animal models of elevated IOP as well as glaucoma in humans. The ocular hypotensive effects of Apraclonidine are usually attributed to reduced aqueous humor synthesis and vasoconstrictor actions at the anterior segment branches of the ophthalmic artery.Apraclonidine (1.15%, single instillation) inhibits 98% of PGE2-induced aqueous flare elevationy.Animal Model:male rabbits.Dosage:1.15% Administration:Apraclonidine (1.15%, single instillation)Result:Inhibited PGE2-induced elevation of aqueous flare in pigmented rabbits.

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GPCR/G Protein

Adrenergic Receptor

Adrenergic Receptor

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73218-79-8

281.57

C9H11Cl3N4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 125 mg/mL (443.94 mM; 超声助溶 ) H2O 中的溶解度 : ≥ 12.5 mg/mL (44.39 mM)

Cl.Nc1cc(Cl)c(NC2=NCCN2)c(Cl)c1

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(-20℃)

With Ice Pack

≥ 2 years