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Asenapine maleate
CAS No. 85650-56-2
Asenapine maleate ( Org 5222 maleate | Org-5222 maleate | Org5222 maleate )
产品货号. M16209 CAS No. 85650-56-2
Asenapinemaleate (Org 5222) 是一种有效的精神药理学化合物，对 5-HT、多巴胺、组胺和肾上腺素受体具有高亲和力。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥218 | 有现货 |
|
| 10MG | ￥353 | 有现货 |
|
| 25MG | ￥587 | 有现货 |
|
| 50MG | ￥902 | 有现货 |
|
| 100MG | ￥1557 | 有现货 |
|
| 200MG | ￥2691 | 有现货 |
|
| 500MG | ￥4347 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥360 | 有现货 |
|
生物学信息
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产品名称Asenapine maleate
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Asenapinemaleate (Org 5222) 是一种有效的精神药理学化合物，对 5-HT、多巴胺、组胺和肾上腺素受体具有高亲和力。
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产品描述Asenapine maleate (Org 5222) is a potent psychopharmacologic agent that shows high affinity for 5-HT, dopamine, histamine and adrenoceptors; shows much lower affinity (pKi<5) for muscarinic receptor; behaves as a potent antagonist 5-HT receptors (5-HT2A pKB=9.0), dopaime and adrenoceptors; shows strong antipsychotic potential in vivo.Schizophrenia Approved(In Vitro):Relative to its D2 receptor affinity, asenapine has a higher affinity for 5-HT2C, 5-HT2A, 5-HT2B, 5-HT7, 5-HT6, α2B and D3 receptors, suggesting stronger engagement of these targets at therapeutic doses. Asenapine behaves as a potent antagonist (pKB) at 5-HT1A (7.4), 5-HT1B (8.1), 5-HT2A (9.0), 5-HT2B (9.3), 5-HT2C (9.0), 5-HT6 (8.0), 5-HT7 (8.5), D2 (9.1), D3 (9.1), α2A (7.3), α2B (8.3), α2C (6.8) and H1 (8.4) receptors.(In Vivo):Asenapine is an atypical antipsychotic that is currently available for the treatment of schizophrenia and bipolar I disorder. Asenapine may have superior therapeutic effect on anxiety symptoms than other agents in rats. Asenapine has anxiolytic-like effects in the EPM and the defensive marble burying tests in mice.
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体外实验Relative to its D2 receptor affinity, asenapine has a higher affinity for 5-HT2C, 5-HT2A, 5-HT2B, 5-HT7, 5-HT6, α2B and D3 receptors, suggesting stronger engagement of these targets at therapeutic doses. Asenapine behaves as a potent antagonist (pKB) at 5-HT1A (7.4), 5-HT1B (8.1), 5-HT2A (9.0), 5-HT2B (9.3), 5-HT2C (9.0), 5-HT6 (8.0), 5-HT7 (8.5), D2 (9.1), D3 (9.1), α2A (7.3), α2B (8.3), α2C (6.8) and H1 (8.4) receptors.
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体内实验Asenapine is an atypical antipsychotic that is currently available for the treatment of schizophrenia and bipolar I disorder. Asenapine may have superior therapeutic effect on anxiety symptoms than other agents in rats. Asenapine has anxiolytic-like effects in the EPM and the defensive marble burying tests in mice.
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同义词Org 5222 maleate | Org-5222 maleate | Org5222 maleate
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通路GPCR/G Protein
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靶点Adrenergic Receptor
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受体5-HT2A|5-HT2B|5-HT2C|5-HT6|5-HT7
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研究领域Neurological Disease
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适应症Schizophrenia
化学信息
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CAS Number85650-56-2
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分子量401.8402
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分子式C21H20ClNO5
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESCN1C[C@H]2[C@H](C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24.C(=C\C(=O)O)\C(=O)O
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化学全称1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-methyl-, (3aR,12bR)-rel-, (2Z)-2-butenedioate (1:1)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Room P, et al. Eur J Pharmacol. 1991 Dec 3;205(3):233-40.
2. Broekkamp CL, et al. Arzneimittelforschung. 1990 May;40(5):544-9.
3. Psychopharmacology (Berl). 2008 Feb;196(3):417-29.
4. Shahid M, et al. J Psychopharmacol. 2009 Jan;23(1):65-73.
产品手册
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