RTC-5 ( —— )

产品货号. M33111 CAS No. 1423077-49-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

RTC-5
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

RTC-5 (TRC-382) 是一种具有抗癌效力的优化吩噻嗪。RTC-5 显示针对 EGFR 驱动的癌症的异种移植模型的功效，其效果归因于 PI3K-AKT 和 RAS-ERK 信号传导的负调节。
产品描述

RTC-5 (TRC-382) is an optimized phenothiazine with anti-cancer potency. RTC-5 demonstrates efficacy against a xenograft model of an EGFR driven cancer, its effects is attributed to concomitant negative regulation of PI3K-AKT and RAS-ERK signaling.
体外实验

RTC-5 (0-40 μM; 48 hours) inhibits H1650 lung adenocarcinoma cell growth with an GI50 of 12.6μM.RTC-5 (20-40 μM; 24 hours) negatively regulates PI3K-AKT and RAS-ERK pathways by decreasing phospho-AKT and phospho-ERK levels expression.Cell Viability AssayCell Line:H1650 lung adenocarcinoma cells Concentration:0 μM, 1 μM, 10 μM, 20 μM, 30 μM, 40 μM Incubation Time:48 hours Result:Inhibited H1650 lung adenocarcinoma cell growth. Western Blot Analysis Cell Line:H1650 lung adenocarcinoma cells Concentration:20 μM, 40 μM Incubation Time:24 hours Result:Decreased p-AKT, p-ERK expression.
体内实验

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同义词

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通路

Angiogenesis
靶点

EGFR
受体

EGFR
研究领域

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适应症

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1. Kastrinsky DB, et al.Reengineered tricyclic anti-cancer agents. Bioorg Med Chem. 2015 Oct 1;23(19):6528-34.?

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