AZ7550

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AZ7550 是 AZD9291 的活性代谢物，抑制 IGF1R 的活性，IC50 为 1.6 μM。

AZ7550 (Compound 28) appeares to offer a broadly similar potency and selectivity profile to the parent compound AZD9291. AZ7550 inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo with IC50s of 45, 26, and 786 nM, respectively. AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 with GI50s of 19, 15, and 537 nM, respectively.

AZ7550 (Compound 28) appeares to offer a broadly similar potency and selectivity profile to the parent compound AZD9291. AZ7550 inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo with IC50s of 45, 26, and 786 nM, respectively. AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 with GI50s of 19, 15, and 537 nM, respectively.

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Angiogenesis

EGFR

IC50: 1.6 μM (IGF1R), 88 nM (MLK1), 156 nM (ACK1), 195 nM (ErbB4), 228 nM (MNK2)

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1421373-99-0

485.58

C??H??N?O?

>98% (HPLC)

Soluble in DMSO

CNCCN(C)c1cc(OC)c(Nc2nccc(n2)c3cn(C)c4ccccc34)cc1NC(=O)C=C

2-Propenamide, N-(4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)amino)-2-(methyl(2-(methylamino)ethyl)amino)phenyl)- InChi Key: ZROCWKZRGJYPTG-UHFFFAOYSA-N

(-20℃)

With Ice Pack

≥ 2 years