021-51111890
购物车（）
sales@molnova.cn
EST73502
CAS No. 2307458-82-6
EST73502 ( —— )
产品货号. M28219 CAS No. 2307458-82-6
EST73502 是 μ-阿片受体 (Ki = 64 nM) 激动剂和 σ1 受体 (Ki = 118 nM) 拮抗剂。 EST73502 显示抗伤害活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1511 | 有现货 |
|
| 5MG | ￥3154 | 有现货 |
|
| 25MG | ￥13206 | 有现货 |
|
| 50MG | ￥17205 | 有现货 |
|
| 100MG | ￥25830 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥3477 | 有现货 |
|
生物学信息
-
产品名称EST73502
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述EST73502 是 μ-阿片受体 (Ki = 64 nM) 激动剂和 σ1 受体 (Ki = 118 nM) 拮抗剂。 EST73502 显示抗伤害活性。
-
产品描述EST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity.(In Vivo):In CD1 male mice, EST73502 (10-40 mg/kg; p.o.) shows a dose-response analgesic effect reaching a maximum of 64% and an EC50 of 14 mg/kg in the paw pressure test. EST73502 (5 mg/kg; i.p.) attenuated the expression of mechanical allodynia induced by PSNL, reaching a maximal effect of 56%.
-
体外实验——
-
体内实验——
-
同义词——
-
通路Endocrinology/Hormones
-
靶点Opioid Receptor
-
受体Wnt
-
研究领域——
-
适应症——
化学信息
-
CAS Number2307458-82-6
-
分子量388.88
-
分子式C19H27ClF2N2O2
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESCCN1CC2(CCN(CCC3=CC(F)=CC=C3F)CC2)O[C@H](C)C1=O
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.James E Tarver Jr, et al. Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase. Bioorg Med Chem Lett. 2016 Mar 15;26(6):1525-1528.
产品手册
关联产品
-
Adrenorphin(3TFA)
Adrenorphin(3TFA) 是 μ-阿片受体 (Ki :12 nM) 的激动剂。
-
[Arg14,Lys15]Nocicep...
Highly potent and selective NOP receptor agonist (EC50 = 1 nM). Displays > 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, > 10000 and 1500 for NOP, μ, δ and κ receptors respectively). Longer lasting and 30-fold more potent than nociceptin in vivo; pronociceptive and inhibits locomotor activity.
-
β-Casomorphin, human
β-Casomorphin is an opioid peptide. It was first isolated from an enzymatic digestion of casein that is an agonist at μ opioid receptors.
