Fexofenadine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

非索非那定是一种抗组胺化合物，用于治疗过敏症状，如鼻塞、花粉热和荨麻疹。

Fexofenadine, an antihistamine pharmaceutical drug, is used to treat allergy symptoms, such as nasal congestion, hay fever, and urticaria. Compared to first-generation antihistamines, Fexofenadine is less able to pass the blood-brain barrier and cause sedation.

Fexofenadine (1-100 μM; 1 h) inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner.Fexofenadine (1-100 μM; 1 h) blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts, but shows no effect on either pERK or pJNK.Western Blot Analysis Cell Line:Nasal fibroblasts Concentration:100 μM Incubation Time:1 hour Result:Blocked pp38 activation in histamine-induced nasal fibroblasts, showed histamine-induced IL-6 production mediated by the p38 pathway.

Fexofenadine hydrochloride (oral administration; 5-20 mg/kg; once daily; 3 w) suppresses both eosinophilia and systemic anaphylaxis in C57BL/6 mice infected with T. spiralis. Animal Model:C57BL/6 mice infected with Trichinella spiralis Dosage:5, 10 and 20 mg/kg Administration:Oral administration; 5, 10 and 20 mg/kg; once daily; 3 weeks Result:Inhibited eosinophilia in a dose-dependent manner.Suppressed the decrease in rectal temperature (p<0.01), a marker for systemic anaphylaxis.

Carboxyterfenadine | Allegra | MDL 16.455 | Telfast | Carboxyterfenadine

GPCR/G Protein

Histamine Receptor

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83799-24-0

501.667

C32H39NO4

>98% (HPLC)

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CC(C)(C(O)=O)c1ccc(cc1)C(O)CCCN1CCC(CC1)C(O)(c1ccccc1)c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years