Hydroxyzine dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Hydroxyzine DiHClide 是一种组胺 H1 受体拮抗剂。

Hydroxyzine Dihydrochloride is a histamine H1-receptor antagonist.(In Vitro):Hydroxyzine dihydrochloride inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min.(In Vivo):Hydroxyzine dihydrochloride (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine dihydrochloride (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats.

Hydroxyzine dihydrochloride inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min.

Hydroxyzine dihydrochloride (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine dihydrochloride (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats.

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GPCR/G Protein

Histamine Receptor

H1 receptor

Inflammation/Immunology

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2192-20-3

447.83

C21H27ClN2O2·2HCl

>98% (HPLC)

Ethanol: 15 mg/mL (33.49 mM); Water: 90 mg/mL (200.96 mM); DMSO: 90 mg/mL (200.96 mM)

Cl.Cl.OCCOCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=C(Cl)C=C1

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(-20℃)

With Ice Pack

≥ 2 years