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JHU 37152
CAS No. 2369979-67-7
JHU 37152 ( —— )
产品货号. M24084 CAS No. 2369979-67-7
JHU 37152 是一种仅由设计药物 (DREADD) 激动剂激活的设计受体，体外人毒蕈碱乙酰胆碱 M3 受体 (hM3Dq) 和 hM4Di 的 Ki 值分别为 1.8 nM 和 8.7 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥103 | 有现货 |
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| 25MG | ￥201 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
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| 1 mL x 10 mM in DMSO | ￥110 | 有现货 |
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生物学信息
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产品名称JHU 37152
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述JHU 37152 是一种仅由设计药物 (DREADD) 激动剂激活的设计受体，体外人毒蕈碱乙酰胆碱 M3 受体 (hM3Dq) 和 hM4Di 的 Ki 值分别为 1.8 nM 和 8.7 nM。
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产品描述JHU 37152 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively.?And EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.
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体外实验JHU37152 displays high DREADD affinity, with Kis of 1.8?nM and 8.7?nM for hM3Dq and hM4Di expressed in mouse brain sections.JHU37152 (1-1000 nM) selectively displaces [3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites.
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体内实验JHU37152 (0.1 mg/kg; i.p.) exhibits high DREADD occupancy in mice and rats.JHU37152 (0.01-1 mg/kg; i.p.) selectively inhibits locomotor activity in D1-hM3Dq and D1-hM4Di mice without any significant locomotor effects observed in WT mice.
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同义词——
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通路Endocrinology/Hormones
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靶点AChR
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受体M3 mAChR
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研究领域——
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适应症——
化学信息
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CAS Number2369979-67-7
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分子量358.85
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分子式C19H20ClFN4
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纯度>98% (HPLC)
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溶解度DMSO:72 mg/mL (200.65 mM);Ethanol:24 mg/mL (66.88 mM)
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SMILESFC1=C2C(NC3=CC=C(Cl)C=C3N=C2N4CCN(CC)CC4)=CC=C1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Bonaventura J , Eldridge M , Hu F , et al. High-potency ligands for DREADD imaging and activation in rodents and monkeys[J]. Nature Communications, 2019, 10(1).
