Pentostatin
CAS No. 53910-25-1
Pentostatin ( CI 825 | CL 67310465 | DCF | Deoxycoformycin | NSC 218321 | NSC 247520 )
产品货号. M14925 CAS No. 53910-25-1
喷司他丁是一种极其有效的 (Ki = 2.5 pM)、不可逆的腺苷脱氨酶抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ¥225 | 有现货 |
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| 5MG | ¥406 | 有现货 |
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| 10MG | ¥653 | 有现货 |
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| 25MG | ¥1423 | 有现货 |
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| 50MG | ¥2483 | 有现货 |
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| 100MG | ¥3501 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
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| 1 mL x 10 mM in DMSO | ¥520 | 有现货 |
|
生物学信息
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产品名称Pentostatin
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述喷司他丁是一种极其有效的 (Ki = 2.5 pM)、不可逆的腺苷脱氨酶抑制剂。
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产品描述Pentostatin is an extremely potent (Ki = 2.5 pM), irreversible inhibitor of adenosine deaminase. This compound is effective against a variety of cancer cell lines.(In Vitro):In ECP and Pentostatin (CI-825; Deoxycoformycin; 4 mg/m2, i.v.) treatment, all dogs develop granulocytopenia with <500 granulocytes/μL from day 4. Thrombocytopenia (<20,000 platelets/μL) occurs from day 7 after HCT with nadirs of 3000 to 14000 platelets/μL. Pentostatin (2 mg/kg) in combination with cordycepin (2 mg/kg) is 100% effective in the T. evansi-infected mice. There is an increase in levels of some biochemical parameters, especially on liver enzymes, which are accompanied by histological lesions in the liver and kidneys. Pentostatin individually has no curative effect on infected groups.
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体外实验——
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体内实验In ECP and Pentostatin (CI-825; Deoxycoformycin; 4 mg/m2, i.v.) treatment, all dogs develop granulocytopenia with <500 granulocytes/μL from day 4. Thrombocytopenia (<20,000 platelets/μL) occurs from day 7 after HCT with nadirs of 3000 to 14000 platelets/μL. Pentostatin (2 mg/kg) in combination with cordycepin (2 mg/kg) is 100% effective in the T. evansi-infected mice. There is an increase in levels of some biochemical parameters, especially on liver enzymes, which are accompanied by histological lesions in the liver and kidneys. Pentostatin individually has no curative effect on infected groups.
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同义词CI 825 | CL 67310465 | DCF | Deoxycoformycin | NSC 218321 | NSC 247520
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通路Endocrinology/Hormones
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靶点AChR
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受体Adenosine receptor
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研究领域Cancer
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适应症——
化学信息
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CAS Number53910-25-1
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分子量268.27
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分子式C11H16N4O4
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纯度>98% (HPLC)
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溶解度Water: 100 mM; DMSO: 75 mM
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SMILESO[C@H]1C2=C(N([C@H]3O[C@H](CO)[C@@H](O)C3)C=N2)N=CNC1
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化学全称(R)-3-((2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. nabhan, et Al. Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. Leukemia Res. 28 429.
产品手册
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