Hydroxyzine free base

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Hydroxyzine 是组胺 H1 受体的拮抗剂。羟嗪是一种具有镇静作用的抗组胺药，用于控制焦虑和呕吐。

Hydroxyzine is an antagonist of histamine H1-receptor. Hydroxyzine is an antihistaminic with sedative properties used in the control of anxiety and emesis.

Hydroxyzine dihydrochloride inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min.

Hydroxyzine dihydrochloride (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine dihydrochloride (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats.

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GPCR/G Protein

Histamine Receptor

H1 receptor

nervous system

Agitation on Recovery From Sedation

68-88-2

374.9

C21H27ClN2O2?

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (266.74 mM)

OCCOCCN1CCN(CC1)C(c1ccccc1)c1ccc(Cl)cc1

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(-20℃)

With Ice Pack

≥ 2 years