Fexofenadine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

盐酸非索非那定（Allegra）是一种抗组胺药，用于治疗花粉热和类似的过敏症状。

Fexofenadine hydrochloride (Allegra) is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine. Fexofenadine, like other second and third-generation antihistamines, does not readily pass through the blood-brain barrier, and so causes less drowsiness than first-generation histamine-receptor antagonists.(In Vitro):Fexofenadine (1-100 μM; 1 h) inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner.Fexofenadine (1-100 μM; 1 h) blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts, but shows no effect on either pERK or pJNK.(In Vivo):Fexofenadine hydrochloride (oral administration; 5-20 mg/kg; once daily; 3 w) suppresses both eosinophilia and systemic anaphylaxis in C57BL/6 mice infected with T. spiralis.

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GPCR/G Protein

Histamine Receptor

H1 receptor

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138452-21-8

538.12

C32H4OCINO4

>98% (HPLC)

DMSO: 10 mM

[H+].[Cl-].CC(C)(C(O)=O)C1=CC=C(C=C1)C(O)CCCN1CCC(CC1)C(O)(C1=CC=CC=C1)C1=CC=CC=C1

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(-20℃)

With Ice Pack

≥ 2 years