Fexofenadine hydrochloride ( —— )

产品货号. M11597 CAS No. 138452-21-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Fexofenadine hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

盐酸非索非那定（Allegra）是一种抗组胺药，用于治疗花粉热和类似的过敏症状。
产品描述

Fexofenadine hydrochloride (Allegra) is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine. Fexofenadine, like other second and third-generation antihistamines, does not readily pass through the blood-brain barrier, and so causes less drowsiness than first-generation histamine-receptor antagonists.(In Vitro):Fexofenadine (1-100 μM; 1 h) inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner.Fexofenadine (1-100 μM; 1 h) blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts, but shows no effect on either pERK or pJNK.(In Vivo):Fexofenadine hydrochloride (oral administration; 5-20 mg/kg; once daily; 3 w) suppresses both eosinophilia and systemic anaphylaxis in C57BL/6 mice infected with T. spiralis.
体外实验

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体内实验

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同义词

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通路

GPCR/G Protein
靶点

Histamine Receptor
受体

H1 receptor
研究领域

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适应症

——

CAS Number

138452-21-8
分子量

538.12
分子式

C32H4OCINO4
纯度

>98% (HPLC)
溶解度

DMSO: 10 mM
SMILES

[H+].[Cl-].CC(C)(C(O)=O)C1=CC=C(C=C1)C(O)CCCN1CCC(CC1)C(O)(C1=CC=CC=C1)C1=CC=CC=C1
化学全称

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1.Abbas MN, et al. Anal Sci. 2004 Aug;20(8):1137-42.

计算器

产品手册

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Pitolisant

一种有效且选择性的 H3 受体拮抗剂，Ki/EC50 为 0.16/1.5 nM；对H1、H2、H4受体没有影响（IC50>10 uM）。