Esculetin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Esculetin 是一种主要从花曲柳 (Fraxinus rhynchophylla) 的树皮中提取的活性成分。 Esculetin 通过抑制 PI3K/Akt 途径来抑制血小板衍生生长因子 (PDGF) 诱导的气道平滑肌细胞 (ASMCs) 表型转换。Esculetin 具有抗氧化，抗炎和抗肿瘤的作用。

Esculetin is a β-catenin inhibitor found in chicory and other plant sources. It displays a wide variety of activities, including inhibiting MPTP-induced neurotoxicity and neuronal apoptosis, decreasing body weight, triglyceride levels, total cholesterol and glucose levels in high-fat diet-fed animals, and suppressing proliferation of colon cancer cells.

Western Blot Analysis Cell Line:PANC-1 cells Concentration:100 μM Incubation Time:0-12 h Result:Increased the amount of phosphorylated form of Nrf2.Increased the levels of Nrf2 in nuclear.Decreased NF-κB protein levels.

Animal Model:Imiquimod (HY-B0180) (IMQ)-induced psoriatic mice Dosage:50 and 100 mg/kg/day Administration: p.o., 7d Result:Ameliorated the skin lesion and reduced the PASI score.Inhibited epidermal hyperplasia, and CD8 expression in the skin of psoriatic mice.

Asculetine | CCRIS 7065 | CCRIS-7065 | CCRIS7065

GPCR/G Protein

Histamine Receptor

Others

Cancer

——

305-01-1

178.14

C9H6O4

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (701.70 mM)

c1cc(=O)oc2cc(c(cc12)O)O

6,7-dihydroxy-2H-chromen-2-one

(-20℃)

With Ice Pack

≥ 2 years