Halobetasol Propionate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

丙酸卤倍他索是卤倍他索的丙酸盐形式，卤倍他索是一种合成皮质类固醇，具有抗炎、止痒和血管收缩活性。

Halobetasol Propionate is the propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses across cell membranes to interact with cytoplasmic corticosteroid receptors located in both the dermal and intradermal cells, thereby activating gene expression of anti-inflammatory proteins mediated via corticosteroid receptor response element. Specifically, this agent induces phospholipase A2 inhibitory proteins, which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes. As a result, halobetasol reduces edema, erythema, and pruritus through its cutaneous effects on vascular dilation and permeability.

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BMY-30056 | CGP-14458 | Ulobetasol propionate

GPCR/G Protein

Histamine Receptor

PLA2

Others-Field

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66852-54-8

484.96

C25H31ClF2O5

>98% (HPLC)

DMSO : ≥ 35 mg/mL; 72.17 mM

C(=O)(CC)O[C@@]1([C@H](C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@]12C)O)F)C)F)C)C(=O)CCl

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(-20℃)

With Ice Pack

≥ 2 years