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AG 494
CAS No. 133550-35-3
AG 494 ( AG-494 | AG 494 | AG494 | Tyrphostin AG-494. )
产品货号. M17249 CAS No. 133550-35-3
AG-494 是表皮生长因子受体激酶的抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥148 | 有现货 |
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| 10MG | ￥250 | 有现货 |
|
| 25MG | ￥492 | 有现货 |
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| 50MG | ￥801 | 有现货 |
|
| 100MG | ￥1305 | 有现货 |
|
| 200MG | ￥1863 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥159 | 有现货 |
|
生物学信息
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产品名称AG 494
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述AG-494 是表皮生长因子受体激酶的抑制剂。
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产品描述AG-494, also known as Tyrphostin AG-494, is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 1 μM in HT-22 cells
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体外实验In DHER-14 cells, AG 494 inhibits Cdk2 activation and EGF-dependent DNA synthesis.AG-494 significantly prevents NF-kB activation in silica-stimulated cells, and also reduces NF-kB activation in H2O2-treated cells.AG-494 (3-9 μM; 5-7 days) inhibits BMP9-induced ALP activity in a dose-dependent manner.
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体内实验——
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同义词AG-494 | AG 494 | AG494 | Tyrphostin AG-494.
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通路Immunology/Inflammation
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靶点TLR
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受体EGFR
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研究领域Cancer
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适应症——
化学信息
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CAS Number133550-35-3
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分子量280.28
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分子式C16H12N2O3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (356.79 mM)
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SMILESc1ccc(cc1)NC(=O)/C(=C/c1cc(c(cc1)O)O)/C#N
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化学全称2E-cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Gazit, A. et al. Tyrphostins I: Synthesis and biological activity of protein tyrosine kinase inhibitors. Journal of Medicinal Chemistry 32(10), 2344-2352 (1989).
产品手册
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