BBIQ

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BBIQ 是一种强大的疫苗佐剂，可增强先天免疫反应，它是一种咪唑喹啉化合物，也是一种有效且选择性的 Toll 样受体 7 (TLR7) 激动剂，对人 TLR7 的 EC50 为 59.1 nM。

BBIQ is a powerful vaccine adjuvant that enhances innate immune responses[2] and it is a imidazoquinoline compound and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC50 of 59.1 nM for human TLR7.(In Vitro):BBIQ induces IFN-α in human PBMCs (520?pg/mL at 5?μg/mL).(In Vivo):In mice treated with Chloroquine (CQ) alone, parasite (P. berghei ANKA) appearesd on Day 17 and all mice of this group died by Day 21. Mice treated with BBIQ along with CQ exhibits no appearance of parasite till Day 23. Frequencies of T cells (CD3+, CD4+and CD8+) and T regulatory cells (CD4+, CD25 +and FoxP3+) are lower in brain of BBIQ?+?CQ treated mice as compared to BBIQ alone and CQ alone treated mice on Day 10. Serum levels of IFN-γ and IL-12 are higher on same day in mice treated with BBIQ?+?CQ which reveals the generation of strong Th1 immune response in mice against the infection. Inhibition of infiltration of inflammatory T cells and activation of T helper and T cytotoxic cells against the parasite is observed in the mice treated with this combination therapy.

BBIQ induces IFN-α in human PBMCs (520?pg/mL at 5?μg/mL).

In mice treated with Chloroquine (CQ) alone, parasite (P. berghei ANKA) appearesd on Day 17 and all mice of this group died by Day 21. Whereas, mice treated with BBIQ along with CQ exhibits no appearance of parasite till Day 23. Frequencies of T cells (CD3+, CD4+and CD8+) and T regulatory cells (CD4+, CD25 +and FoxP3+) are lower in brain of BBIQ?+?CQ treated mice as compared to BBIQ alone and CQ alone treated mice on Day 10. Inhibition of infiltration of inflammatory T cells and activation of T helper and T cytotoxic cells against the parasite is observed in the mice treated with this combination therapy. Serum levels of IFN-γ and IL-12 are higher on same day in mice treated with BBIQ?+?CQ which reveals the generation of strong Th1 immune response in mice against the infection.

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Immunology/Inflammation

TLR

B. anthracis| S. aureus

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1229024-57-0

330.435

C21H22N4

>98% (HPLC)

In Vitro:?DMSO : 16.67 mg/mL (50.45 mM)

CCCCc1nc2c(N)nc3ccccc3c2n1Cc1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years