Aumitin ( Aumitin )

产品货号. M16783 CAS No. 946293-78-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Aumitin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Aumitin 是一种新型有效的自噬抑制剂，针对饥饿和雷帕霉素诱导的自噬的 IC50 分别为 124 和 244 nM。
产品描述

Aumitin is a novel potent autophagy inhibitor with IC50 of 124 and 244 nM against starvation- and rapamycin- induced autophagy respectively, targets mitochondrial complex I; inhibits LC3 lipidation, and p62 degradation by starvation- as well as rapamycin-induced autophagy dose-dependently in MCF7-LC3 cells, suggesting inhibition of autophagic flux; inhibits mitochondrial respiration by targeting complex I with IC50 of 0.11 uM in HeLa cells; Aumitin is a new tool compound for interrogating autophagy and mitochondrial respiration by means of complex I inhibition.
体外实验

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体内实验

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同义词

Aumitin
通路

Autophagy
靶点

Autophagy
受体

Autophagy
研究领域

——
适应症

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CAS Number

946293-78-3
分子量

429.908
分子式

C24H20ClN5O
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 100 mg/mL (232.61 mM)
SMILES

O=C(NC1=CC=C(NC2=NC(NC3=CC=CC=C3)=CC(C)=N2)C=C1)C4=CC=CC=C4Cl
化学全称

2-chloro-N-(4-((4-methyl-6-(phenylamino)pyrimidin-2-yl)amino)phenyl)benzamide

1. Robke L, et al. Chem Sci. 2018 Feb 26;9(11):3014-3022.

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