Euxanthone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Euxanthone 是一种氧杂蒽酮衍生物，可通过触发自噬 (autophagy) 来减弱 Aβ1-42 诱导的氧化应激和细胞凋亡。Euxanthone 具有抗肿瘤和神经保护活性。

Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities.

Cell Migration Assay Cell Line:Osteosarcoma (OS) cells Concentration:10 μM, 20 μM Incubation Time:24 h Result:Inhibited cell migration at 24 hr. Western Blot Analysis Cell Line:Osteosarcoma (OS) cells,Concentration:10 μM, 20 μM Incubation Time:24 h Result:Repressed both the mRNA and protein level of COX-2 in OS cells in a dose-dependent fashion.

Animal Model:Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion Dosage:30 mg/kg, 60 mg/kg Administration:p.o.;once a day; for 7 days Result:Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown.

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Autophagy

Autophagy

Autophagy

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529-61-3

228.2

C13H8O4

>98% (HPLC)

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O=C1C2=CC(O)=CC=C2OC=3C=CC=C(O)C13

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(-20℃)

With Ice Pack

≥ 2 years