Thonzonium Bromide ( —— )

产品货号. M15007 CAS No. 553-08-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Thonzonium Bromide
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

松宗溴化物是一种单阳离子洗涤剂。
产品描述

Thonzonium bromide is a monocationic detergent.(In Vitro):Thonzonium bromide inhibits RANKL-induced OC formation, the appearance of OC-specific marker genes and bone-resorbing activity in vitro. Thonzonium bromide blocks the RANKL-induced activation of NF-κB, ERK and c-Fos as well as the induction of NFATc1 which is essential for OC formation. Thonzonium bromide disrupts F-actin ring formation resulting in disturbances in cytoskeletal structure in mature OCs during bone resorption. Thonzonium bromide exhibits protective effects in an in vivo murine model of LPS-induced calvarial osteolysis.
体外实验

Thonzonium bromide inhibits RANKL-induced OC formation, the appearance of OC-specific marker genes and bone-resorbing activity in vitro. Thonzonium bromide blocks the RANKL-induced activation of NF-κB, ERK and c-Fos as well as the induction of NFATc1 which is essential for OC formation. Thonzonium bromide disrupts F-actin ring formation resulting in disturbances in cytoskeletal structure in mature OCs during bone resorption. Thonzonium bromide exhibits protective effects in an in vivo murine model of LPS-induced calvarial osteolysis.
体内实验

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同义词

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通路

Autophagy
靶点

Autophagy
受体

DHPS
研究领域

Infection
适应症

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计算器

产品手册

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