Aclidinium bromide ( LAS 34273 | LAS-W 330 )

产品货号. M14042 CAS No. 320345-99-1

Aclidinium Bromide 抑制人毒蕈碱 AChR M1、M2、M3、M4 和 M5，Ki 分别为 0.1 nM、0.14 nM、0.14 nM、0.21 nM 和 0.16 nM。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥471	有现货
10MG	￥708	有现货
25MG	￥1237	有现货
50MG	￥1823	有现货
100MG	￥2511	有现货
500MG	￥5778	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥585	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Aclidinium bromide
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Aclidinium Bromide 抑制人毒蕈碱 AChR M1、M2、M3、M4 和 M5，Ki 分别为 0.1 nM、0.14 nM、0.14 nM、0.21 nM 和 0.16 nM。
产品描述

Aclidinium Bromide inhibits human muscarinic AChR M1, M2, M3, M4 and M5 with Ki of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM and 0.16 nM, respectively.(In Vitro):Preclinically, aclidinium showed potent antagonism of human muscarinic receptors, with a long residence time at M3 receptors and a shorter residence time at M2 receptors, indicating the potential to provide sustained bronchodilation. Aclidinium is rapidly hydrolysed in human plasma, unlike other currently available antimuscarinics including tiotropium. Early clinical studies in healthy subjects have confirmed the low systemic bioavailability and favourable safety profile of single and multiple doses of aclidinium. In a subsequent Phase IIb study, which included 464 patients with moderate to severe COPD, aclidinium displayed long-lasting bronchodilatory activity and was well tolerated.
体外实验

Preclinically, aclidinium showed potent antagonism of human muscarinic receptors, with a long residence time at M3 receptors and a shorter residence time at M2 receptors, indicating the potential to provide sustained bronchodilation. Aclidinium is rapidly hydrolysed in human plasma, unlike other currently available antimuscarinics including tiotropium. Early clinical studies in healthy subjects have confirmed the low systemic bioavailability and favourable safety profile of single and multiple doses of aclidinium. In a subsequent Phase IIb study, which included 464 patients with moderate to severe COPD, aclidinium displayed long-lasting bronchodilatory activity and was well tolerated.
体内实验

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同义词

LAS 34273 | LAS-W 330
通路

Endocrinology/Hormones
靶点

AChR
受体

M1 mAChR| M2 mAChR| M3 mAChR| M4 mAChR| M5 mAChR
研究领域

Inflammation/Immunology
适应症

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化学信息

CAS Number

320345-99-1
分子量

564.55
分子式

C26H30NO4S2·Br
纯度

>98% (HPLC)
溶解度

DMSO: 113 mg/mL (200.15 mM)
SMILES

O=C(O[C@H]1C[N+]2(CCCOC3=CC=CC=C3)CCC1CC2)C(C4=CC=CS4)(O)C5=CC=CS5.[Br-]
化学全称

[(8R)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octan-8-yl] 2-hydroxy-2,2-dithiophen-2-ylacetate bromide