2′-C-Methyl-6-O-methylinosine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

2′-C-Methyl-6-O-methylinosine 是一种次黄嘌呤类似物。次黄嘌呤是一类主要存在于肌肉组织中的嘌呤碱基，由嘌呤氧化酶作用于黄嘌呤而产生的代谢物。次黄嘌呤有典型的抗炎作用，是潜在的内源性 poly(ADP-ribose) polymerase (PARP) 抑制剂。它通过抑制 PAPR 活性，抑制过氧亚硝酸盐诱导的线粒体去极化和次级超氧化物产生，具有细胞保护性。次黄嘌呤还可以作为缺氧指标。

2′-C-Methyl-6-O-methylinosine is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia.

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Microbiology/Virology

Antibiotic

Nucleoside Antimetabolite/Analog

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565450-78-4

296.28

C12H16N4O5

>98% (HPLC)

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C[C@]1(O)[C@@H](O[C@H](CO)[C@H]1O)N2C=3C(N=C2)=C(OC)N=CN3

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(-20℃)

With Ice Pack

≥ 2 years