Gentamicin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Gentamicin 是一种具有口服活性的氨基糖苷类抗生素，抑制革兰氏阳性菌和革兰氏阴性细菌的生长并可抑制组织培养中的多种支原体菌株。Gentamicin 抑制 DNase I 活性的 IC50 值为 0.57 mM。

Gentamicin, an orally active aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin inhibits DNase I with an IC50 of 0.57 mM.

Gentamicin is a more effective in vitro bacterial inhibitor than combined penicillin-streptomycin, is nontoxic to tissue culture monolayers, and does not inhibit virus replication.Gentamicin has been used with success as an additive in commercial mycology media to inhibit growth of bacteria and has been shown to be bactericidal for a wider range of organisms (Pseudomonas aeruginosa, Proteus sp., and Streptococcus faecalis) than penicillin and streptomycin.Gentamicin does not interfere with the production of cytopathic effect by certain echoviruses and polioviruses in tissue culture, is nontoxic to Rhesus monkey kidney, HeLa, and human amnion cells, and is stable at autoclave temperatures. Gentamicin is produced by various species of the genus Micromonospora. Gentamicin C1a binds in the major groove of the A-site of the RNA.

Gentamicin (oral and injectable forms) exhibits effective antibacterial activity against Yersinia pestis as demonstrated in a mouse infection model.Gentamicin (0.27 g/kg) shows a significant reduction of bacteria on the foreign body in mouse.

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Microbiology/Virology

Antibiotic

Antibiotic | Antibacterial

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1403-66-3

477.60(Avervage)

C21H43N5O7

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years