VP-4604

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

VP-4604 是一种有效的耐甲氧西林金黄色葡萄球菌 (MRSA) 剂。VP-4604 显著抑制金黄色葡萄球菌 (ATCC 43300) 生长，MIC 为 4-8 μg/mL。VP-4604 抑制耐甲氧西林金黄色葡萄球菌生长，生长抑制达 95% 以上。

VP-4604 is a potent anti-methicillin-resistant Staphylococcus aureus (MRSA) agent. VP-4604 exhibits significant microbial growth inhibition toward Staphylococcus aureus (ATCC 43300) with MIC of 4-8 μg/mL. VP-4604 inhibits the growth of methicillin‐resistant Staphylococcus aureus with growth inhibition >95%.

VP-4604 (2.5 mM, 18 hours) inhibits drug-resistant S. aureus and P. aeruginosa with growth inhibiton (%) GI >95%.VP-4604 shows low cytotoxicity with a CC50 value >118.4 mM towards HEK-293 (human embryonic kidney) ATCC CRL‐1573 and an HC10 vaule >118.4 μM towards RBC (human red blood cells) .VP-4604 (2.5 mM) is tolerated by mammalian cells (HaCaT, lymphocytes) with the inhibition growth (%) of 44.1% and >50%, respectively.Cell Proliferation Assay Cell Line:S. aureus ATCC25923, P. aeruginosa ATCC9027 Concentration:0.625 mM, 1.25 mM, 2.5 mM Incubation Time:18 hours Result: Showed antibacterial effect.Cell Cytotoxicity Assay Cell Line:HaCaT line (human keratinocytes), lymphocytes (from healthy adult human peripheral blood) Concentration:0, 1, 10, 100, 1000, 2500 μM Incubation Time:48 or 72 hours Result:Showed low toxicity towards mammalian cells.

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Microbiology/Virology

Antibiotic

Antibiotic | Antibacterial

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64268-93-5

270.3

C11H14N2O4S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 25 mg/mL (92.49 mM; 超声助溶 (<60°C)

[O-][N+](=O)c1ccc(cc1)S(=O)(=O)N1CCCCC1

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(-20℃)

With Ice Pack

≥ 2 years