Xanthine Oxidase (XAO)
The 6-oxopurine, xanthine (Xan, 2,6-dioxopurine), and its nucleosides and nucleotides are involved in a variety of intracellular metabolic pathways as substrates and/or intermediates of numerous enzymes or enzyme systems, e.g. Xan, a substrate of both xanthine oxidase (XO) and xanthine dehydrogenase, is an intermediate in the formation, from Hyp, of urate, the end product of purine nucleotide catabolism. This enzyme and xanthine dehydrogenase, interconvertible (by proteolysis or disulfide formation) forms of the same gene product known as xanthine oxidoreductase, catalyzes the oxidation of many purines and related analogues. In mammalian systems it catalyzes the last two steps of purine catabolism, the oxidation of Hyp to xanthine and of Xan to uric acid. The initial methyl acceptor for caffeine biosynthesis in tea and coffee plants is is xanthosine (Xao) and/or xanthosine-5 -phosphate (XMP). XMP is an intermediate in the formation of GMP from IMP by IMP dehydrogenase. XTP is as efficient a phosphate donor as ATP for human deoxycytidine kinase. In purine salvage pathways, some purine phosphoribosyltransferases (PRTase) will accept xanthine, in several instances with high selectivity relative to other purines.
References
1.Kulikowska E,et al. Acta Biochim Pol. 2004;51(2):493–531.
References
1.Kulikowska E,et al. Acta Biochim Pol. 2004;51(2):493–531.
Metabolic Enzyme/Protease
11β-HSD(15)
15-PGDH(1)
ACC(10)
ACE(15)
AChE(47)
Adenylate Cyclase(12)
ALDH(14)
Aldose Reductase(5)
Aminopeptidase(19)
BACE(19)
Casein Kinase(51)
CAT(5)
Cathepsin(9)
CETP(13)
COMT(2)
CPG2(1)
CYPs(6)
Decarboxylase(3)
Dehydrogenase(131)
DGAT(4)
Dopamine beta-hydroxylase(2)
DPP(32)
Elastase(6)
FAAH(28)
Factor Xa(31)
Fatty Acid Synthase(17)
Ftase(2)
FXR(26)
Glucokinase(1)
GSNOR(2)
Guanylate Cyclase(13)
HMGCR(17)
IDH(7)
IDO(20)
IMPDH(2)
LDH(2)
LDL(8)
Lipase(17)
Lipid(12)
MAGL(6)
MAO(72)
MMP(78)
NAMPT(12)
Neprilysin(7)
Other Targets(10)
P450(112)
PAI-1(9)
Phosphatase(95)
Phospholipase(65)
PPAR(115)
Protein Phosphatase/PTP(6)
Renin(8)
Retinoid Receptor(37)
SCD(6)
Steroid Sulfatase (STS)(2)
Thioredoxin(1)
TPH(5)
Transferase(37)
Vitamin(44)
Xanthine Oxidase (XAO)(11)
Xanthine Oxidase (XAO)
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Xanthine oxidoreductase-IN-5
产品货号 : M36446
cas no: 1026652-90-3
Xanthine oxidoreductase-IN-5 是一种具有口服活性的黄氨酸氧化还原酶 (XOR) 抑制剂,IC50 值为 55 nM。Xanthine oxidoreductase-IN-5 可用于研究急性高尿酸血症。 -
Xanthine oxidoreductase-IN-3
产品货号 : M36445
cas no: 651769-78-7
Xanthine oxidoreductase-IN-3 是一种具有口服活性的黄氨酸氧化还原酶 (XOR) 抑制剂,IC50 值为 26.3 nM。Xanthine oxidoreductase-IN-3 可用于研究急性高尿酸血症。 -
Xanthine oxidoreductase-IN-4
产品货号 : M36437
cas no: 1026587-58-5
Xanthine oxidoreductase-IN-4 是一种黄嘌呤氧化还原酶 (XOR) 抑制剂,具有口服活性。Xanthine oxidoreductase-IN-4 对 XOR 具有抑制活性,IC50 值为 29.3 nM。Xanthine oxidoreductase-IN-4 可用于高尿酸血症的研究。 -
Tigulixostat
产品货号 : M35447
cas no: 1287766-55-5
Tigulixostat (LC350189) 是一种具有口服活性的非嘌呤选择性黄嘌呤氧化酶 (xanthine oxidase) 抑制剂。Tigulixostat 降低尿酸的产生,可用于痛风和高尿酸血症研究。 -
Xanthine oxidase-IN-1
产品货号 : M32805
cas no: 1071970-13-2
Xanthine oxidase-IN-1是黄嘌呤氧化酶 (xanthine oxidase) 抑制剂,来自专利WO2008126898A1,第68页,化合物实施例3,IC50 值为6.5 nM。