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11β-HSD

11β-HSD catalyze interconversion of active cortisol and corticosterone with inert cortisone and 11-dehydrocorticosterone. 11β-HSD type 1, a predominant reductase in most intact cells, catalyzes the regeneration of active glucocorticoids, thus amplifying cellular action; 11β-HSD2 is a high-affinity dehydrogenase that inactivates glucocorticoids. In the distal nephron, 11β-HSD2 ensures that only aldosterone is an agonist at mineralocorticoid receptors (MR).The 11β-HSDs thus illuminate the emerging biology of intracrine control, afford important insights into human pathogenesis, and offer new tissue-restricted therapeutic avenues.

References:

1.Chapman K, et al. Physiol Rev. 2013 Jul;93(3):1139-206.

Metabolic Enzyme/Protease

11β-HSD(15) 15-PGDH(1) ACC(10) ACE(15) AChE(47) Adenylate Cyclase(12) ALDH(14) Aldose Reductase(5) Aminopeptidase(19) BACE(19) Casein Kinase(51) CAT(5) Cathepsin(9) CETP(13) COMT(2) CPG2(1) CYPs(6) Decarboxylase(3) Dehydrogenase(131) DGAT(4) Dopamine beta-hydroxylase(2) DPP(32) Elastase(6) FAAH(28) Factor Xa(31) Fatty Acid Synthase(17) Ftase(2) FXR(26) Glucokinase(1) GSNOR(2) Guanylate Cyclase(13) HMGCR(17) IDH(7) IDO(20) IMPDH(2) LDH(2) LDL(8) Lipase(17) Lipid(12) MAGL(6) MAO(72) MMP(78) NAMPT(12) Neprilysin(7) Other Targets(10) P450(112) PAI-1(9) Phosphatase(95) Phospholipase(65) PPAR(115) Protein Phosphatase/PTP(6) Renin(8) Retinoid Receptor(37) SCD(6) Steroid Sulfatase (STS)(2) Thioredoxin(1) TPH(5) Transferase(37) Vitamin(44) Xanthine Oxidase (XAO)(11)