palovarotene

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Palovarotene 是核视黄酸受体 γ (RAR-γ) 的激动剂。

Palovarotene, also known as RO-3300074 and R-667, is a highly selective retinoic acid receptor gamma (RAR-γ) agonist that is under investigation as a potential treatment for emphysema. Phase I clinical trials of palovarotene in patients with emphysema demonstrated that the drug is well tolerated, with improvements observed in markers of emphysema progression. Emphysema is characterized by the destruction of alveoli and alveolar ducts within the lungs. Retinoid signaling is believed to play a role in alveologenesis, with the retinoic acid receptor gamma thought to be required for alveolar formation.

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RO-3300074 | RO 3300074 | RO3300074 | R-667

Angiogenesis

c-Met/HGFR

RARγ

Others-Field

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410528-02-8

414.55

C27H30N2O2

>98% (HPLC)

DMSO : 19.5 mg/mL. 47.04 mM;

O=C(O)c1ccc(cc1)/C=C/c3cc4c(cc3Cn2cccn2)C(C)(C)CCC4(C)C

4-((1E)-2-(5,5,8,8-Tetramethyl-3-(1H-pyrazol-1-ylmethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl)benzoic acid

(-20℃)

With Ice Pack

≥ 2 years