YTX-465

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

YTX-465 是硬脂酰辅酶 A 去饱和酶 (IC50s = 39 nM) 和 Ole1 (IC50s = 30.4 μM) 的抑制剂。

YTX-465 is an inhibitor of both stearoyl-CoA desaturase(IC50s = 39 nM) and Ole1 (IC50s = 30.4 μM).(In Vitro):YTX-465 rescued growth to a similar magnitude but was >100-fold more potent than YTX-528(EC50 = 0.013 μM). Kinetic growth studies demonstrated that the most effective concentration of YTX-465 (0.050 μM) restored growth rates to that of approximately 40% of the wild-type strain treated with the same concentration of YTX-465. In wild-type yeast, YTX-465 strongly reduced fatty desaturation in a concentration-dependent manner, with a 50% reduction in desaturation at 0.03 μM YTX-465.

YTX-465 (1-10000 nM) has an EC50 value of 0.013 μM for α-synuclein (α-syn) toxicity rescue.YTX-465 (0.05 μM; 0-2 days) rescue the growth of α-Syn-expressing yeast.YTX-465 (0, 10, 40, 160, 640, 2500 nM; 4h) increases the level of Ole1 protein in wild-type yeast expressing OLE1 in a concentration-dependent manner, that indicate YTX-465 induce a negative feedback loop.YTX-465 (0, 0.03, 0.09, 0.27, 0.81 μM; 6 hours) reduces fatty desaturation in a concentration-dependent manner in wild-type yeast, with a 50% reduction in desaturation at 0.03 μM.YTX-465 (0.25 μM; 8 hours) decreases the desaturation index (DI) for all major classes of membrane phospholipids in wild-type yeast.

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Metabolic Enzyme/Protease

SCD

EML4-ALK

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2225824-53-1

458.51

C25H26N6O3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (218.10 mM)

Cc1nn(C)c2c1ccc(-c1noc(C(CC3)CCN3C(CNC(c3ccccc3)=O)=O)n1)c2

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(-20℃)

With Ice Pack

≥ 2 years