Spiroxatrine ( —— )

产品货号. M33930 CAS No. 1054-88-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Spiroxatrine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Spiroxatrine (R 5188) 是一种选择性的 5-HT1α 和 α-肾上腺素能 (α2-adrenergic) 双拮抗剂，对5-HT1α、5-HT1 β 和 5-HT2 的 Ki 值分别为 3.94、224000、118.5nM。Spiroxatrine (R 5188) 有镇静作用。
产品描述

Spiroxatrine (R 5188) is a selective, dual antagonist of 5-HT1α and α2-adrenergic, with the Ki values of 3.94, 224000, 118.5 nM for 5-HT1α, 5-HT1β and 5-HT2, respectively. Spiroxatrine (R 5188) has a sedative effect.
体外实验

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体内实验

Animal Model:The nerve injury rat model and Carrageenan (HY-125474)-induced rat inflammation model Dosage:1, 10, 25 ug, 5 days Administration:Intraperitoneal injection (i.p.)Result:Increased hindpaw withdrawal latencies to thermal and mechanical stimulation.Animal Model:Fluoxetine (HY-B0102) -induced reduction of ethanol Intake by the P Line of rats Dosage:4 mg/kg/day, 5 mins Administration:Intraperitoneal injection (i.p.)Result:Increased the voluntary oral ethanol intake induced by Fluoxetine (HY-B0102) in the selectively bred alcohol-preferring P line of rats.
同义词

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通路

GPCR/G Protein
靶点

5-HT Receptor
受体

5-HT Receptor | Dopamine Receptor | Adrenergic Receptor
研究领域

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适应症

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1. D L Nelson, et al. Spiroxatrine: a selective serotonin1A receptor antagonist. Eur J Pharmacol. 1986 May 13;124(1-2):207-8.?

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