Citalopram

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Citalopram 是一种包含活性 S(+)-对映体 (Escitalopram；HY-14258) 和 R(-)-对映体的外消旋混合物。Citalopram 是一种具有口服活性的、选择性血清素再摄取抑制剂 (SSRI)。Citalopram是一种抗抑郁药，可增强血清素能神经传递。

Citalopram is a racemate mixture of the active S(+)-enantiomer (Escitalopram; HY-14258) and R(-)-enantiomer. Citalopram is an orally active selective serotonin reuptake inhibitor (SSRI). Citalopram is an antidepressant and enhances serotoninergic neurotransmission.

Cell Cytotoxicity Assay Cell Line:Rat B104, human SH-SY5Y, IMR32 and Kelly neuroblastoma cells Concentration:25, 50, 100, 125, 150, 175 μM Incubation Time:24 h Result:Showed a concentration-dependent cytotoxicity. RT-PCR Cell Line:B104 cells Concentration:100 μM Incubation Time:24 h Result:Strongly down-regulated MYBL2, BIRC5, BARD1, AURKA, CCNA2 and CCNE1 in B104 cells.

Animal Model:Male C57BL/6J and DBA/2J mice, aged 5-7 weeks, 16-20?g Dosage:5-40?mg/kg Administration:IP Result:Reduced immobility time in DBA/2J mice but not in C57BL/6J mice.

——

GPCR/G Protein

5-HT Receptor

5-HT Receptor

——

——

59729-33-8

324.39

C20H21FN2O

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (308.27 mM; 超声助溶 )

CN(C)CCCC1(OCc2cc(ccc12)C#N)c1ccc(F)cc1

——

(-20℃)

With Ice Pack

≥ 2 years