SUVN-502 ( SUVN502 | Masupirdine )

产品货号. M15690 CAS No. 701205-60-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SUVN-502
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SUVN-502 (SUVN502, Masupirdine) 是一种有效、选择性、脑渗透性和口服活性的 5-HT6 受体拮抗剂，Ki 为 2.04 nM。
产品描述

SUVN-502 (SUVN502, Masupirdine)?is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with Ki of 2.04 nM; shows high selectivity over 5-HT2A receptor and other 100 target sites; produces synergistic effects in extracellular levels of acetylcholine in the ventral hippocampus combined with donepezil and memantine; shows potential for treatment of Alzheimer's disease.Alzheimer Disease Phase 2 Clinical.
体外实验

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体内实验

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同义词

SUVN502 | Masupirdine
通路

GPCR/G Protein
靶点

5-HT Receptor
受体

5-HT Receptor
研究领域

Neurological Disease
适应症

Alzheimer Disease

CAS Number

701205-60-9
分子量

478.405
分子式

C21H24BrN3O3S
纯度

>98% (HPLC)
溶解度

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SMILES

CN1CCN(CC1)CC2=CN(C3=C2C=C(C=C3)OC)S(=O)(=O)C4=CC=CC=C4Br
化学全称

1-((2-bromophenyl)sulfonyl)-5-methoxy-3-((4-methylpiperazin-1-yl)methyl)-1H-indole

1. Nirogi R, et al. J Med Chem. 2017 Mar 9;60(5):1843-1859. 2. Nirogi R, et al. J Pharm Biomed Anal. 2017 Apr 14;145:423-430.

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