一种有效的选择性 5-HT1A 受体激动剂，Ki 为 4.8 nM，pKi 为 8.33。

Lecozotan HCl (SRA-333) is a potent and selective 5-HT antagonist that significantly enhances KCl-stimulated glutamate and acetylcholine release from the hippocampal dentate gyrus and has cognitive enhancing properties. Chronic administration of Lecozotan HCl did not induce 5-HT(1A) receptor tolerance or desensitization in a behavioral model demonstrating 5-HT(1A) receptor function.

SB 206553 是一种有效的选择性 5-HT2B/5-HT2C 受体拮抗剂，对大鼠 5-HT2B 的 pA2 为 8.89，对人 5-HT2C 的 pKi 为 7.92，其选择性是其他 5-HT 受体亚型的 80 倍以上。