Roxindole

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Roxindole (EMD 49980)，一种吲哚烷基哌啶，是多巴胺自身受体 (dopamine autoreceptors) 的有效激动剂，在低纳摩尔范围内与 D2 样亚型具有亲和力。Roxindole 可用于研究阳性和阴性精神分裂症症状。Roxindole 是 5-HT1A 激动剂和 5-羟色胺 (5-HT) 的摄取的抑制剂。具有抗精神病药和抗抑郁药活性。

Roxindole (EMD 49980), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor. Antipsychotic and antidepressant activities.

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Roxindole inhibits apomorphine-induced climbing in mice and stereotyped behavior in rats with ED50s of 1.4 mg/kg s.c. and 0.65 mg/kg s.c., respectively, and inhibits conditioned avoidance response in rats (ED50=1.5 mg/kg s.c.).Roxindole (EMD 49980) (1, 3, 10 mg/kg; s.c) inhibits both effects of 8-OH-DPAT (flat body and forepaw treading) in normal rats (male Wistar 200-350g).

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GPCR/G Protein

5-HT Receptor

5-HT Receptor | Dopamine Receptor

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112192-04-8

346.47

C23H26N2O

>98% (HPLC)

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OC=1C=CC=2NC=C(C2C1)CCCCN3CC=C(C=4C=CC=CC4)CC3

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(-20℃)

With Ice Pack

≥ 2 years