(Rac)-WAY-161503

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(Rac)-WAY-161503 是一种有效的，选择性的，高亲和力的 5-HT2C 受体激动剂，Ki 为 4 nM，EC50 为 12 nM。(Rac)-WAY-161503 对 HT2C 的亲和力分别比 5-HT2A 和 5-HT2B 受体高。(Rac)-WAY-161503 具有抗肥胖和抗抑郁的作用。

(Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT2C receptor agonist with a Ki of 4 nM and an EC50 of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT2C than 5-HT2A and 5-HT2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects.

——

Animal Model:Male C57BL/6J mice with hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) Dosage:3 mg/kg, 10 mg/kg, 30 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Dose-dependently decreased locomotor activity, an effect that was blocked by the 5-HT2C/2B antagonist SER-082.

——

GPCR/G Protein

5-HT Receptor

5-HT Receptor

——

——

75704-24-4

272.13

C11H11Cl2N3O

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (367.47 mM; 超声助溶 )

Clc1cc2NC(=O)C3CNCCN3c2cc1Cl

——

(-20℃)

With Ice Pack

≥ 2 years