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5-HT2B antagonist-1
CAS No. 393129-91-4
5-HT2B antagonist-1 ( —— )
产品货号. M37679 CAS No. 393129-91-4
5-HT2B antagonist-1 是一种具有口服活性的 5-HT2B 受体拮抗剂，其 IC50 值为 33.4 nM。可用于以 5-HT2B 受体信号传导为特征的疾病研究，如肝细胞癌、心血管疾病或胃肠道疾病。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥219 | 有现货 |
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| 10MG | ￥358 | 有现货 |
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| 25MG | ￥646 | 有现货 |
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| 50MG | ￥1070 | 有现货 |
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| 100MG | ￥1719 | 有现货 |
|
| 200MG | ￥2493 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥240 | 有现货 |
|
生物学信息
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产品名称5-HT2B antagonist-1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述5-HT2B antagonist-1 是一种具有口服活性的 5-HT2B 受体拮抗剂，其 IC50 值为 33.4 nM。可用于以 5-HT2B 受体信号传导为特征的疾病研究，如肝细胞癌、心血管疾病或胃肠道疾病。
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产品描述5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease.
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体外实验5-HT2B antagonist-1 (compound 5g) has some sodium channel binding activity with IC50 values in the range of 12.6 to 57.5 μM.5-HT2B antagonist-1 (coumpound 1-e) inhibits 5-HT2B receptor activity by less than 50% at 1 μM in CHO-K1 cell lines.
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体内实验5-HT2B antagonist-1 (compound 15) (oral gavage, 30 mg/kg) can reduce visceral hypersensitivity significantly in irritable bowel syndrome (IBS) rats.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number393129-91-4
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分子量296.17
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分子式C11H14BrN5
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : ≥ 33.33 mg/mL (112.54 mM ) H2O 中的溶解度 : 12.5 mg/mL (42.21 mM; 超声助溶 (<60°C)
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SMILESCC1(C)NC(Nc2ccc(Br)cc2)=NC(N)=N1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Xiang Ma, et al. Synthesis and in vitro evaluation of 2,4-diamino-1,3,5-triazine derivatives as neuronal voltage-gated sodium channel blockers. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5644?
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