CCTA-1523 ( —— )

产品货号. M28783 CAS No. 1616271-41-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CCTA-1523
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CCTA-1523 是具有外排功能的 ABCG2 抑制剂。 CCTA-1523 选择性逆转癌细胞中 ABCG2 介导的 MDR。
产品描述

CCTA-1523 is an efflux function of ABCG2 inhibitor. CCTA-1523 selectively reverses ABCG2-mediated MDR in cancer cells.(In Vitro):CCTA-1523 (5μM) sensitized the ABCG2 overexpressing cancer cells and ABCG2 transfected cells to the substrate chemotherapeutic drugs.(In Vivo):Co-administration of CCTA-1523 restored the in vivo antitumor activity of doxorubicin in ABCG2 overexpressing tumor xenografts.
体外实验

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体内实验

Animal Model:NCR nude mice (H460/MX20 xenografts) Dosage:75 mg/kg (DOX ;1.8 mg/kg, i.p., q3d X 6 ) Administration:P.o.;q3d x 6 Result:Significantly inhibited the growth of H460/MX20 tumor xenografts when combined with doxorubicin compared to the vehicle control group.
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