SB-747651A Dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SB-747651A dihydrochloride 是一种 ATP 竞争性的丝裂原和应激激活激酶 1 (MSK1) 抑制剂，IC50 为 11 nM。SB-747651A dihydrochloride 还抑制 PRK2，RSK1，p70S6K 和 ROCK-II。SB-747651A dihydrochloride 可用于炎症研究。

SB-747651A dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A dihydrochloride also inhibits PRK2, RSK1, p70S6K and ROCK-II. SB-747651A dihydrochloride can be used for inflammation research.

SB-747651A dihydrochloride (5 μM; neutrophils) affects CXCL2-induced intraluminal crawling of neutrophils in a Mac-1-dependent manner. SB-747651A dihydrochloride thwarts the intraluminal crawling of adherent neutrophils to optimal sites of emigration. SB-747651A dihydrochloride (5 μM; neutrophils) significantly increases transmigration time and detachment time. SB-747651A dihydrochloride affects mechanisms that regulate transendothelial migration of neutrophils in response to CXCL2 chemotactic gradient. SB-747651A dihydrochloride inhibits the migration speed of extravascular chemotaxing neutrophils but does not affect their directionality in response to CXCL2 chemotactic gradient.

SB747651A (3 mg/kg; intrascrotal injection) dihydrochloride results in increased neutrophil adhesion 3.5~4.5 hours following stimulation with CXCL2 as compared to the effect of CXCL2.SB-747651A (3 mg/kg; i.p.) dihydrochloride affects neutrophil extravasation by increasing neutrophil emigration only at 3 and 4 hours in mouse peritonitis model of acute inflammation.Animal Model:Male C57BL/6N mice (8~16 weeks) Dosage:3 mg/kg Administration:Intrascrotal injection Result:Resulted in increased neutrophil adhesion 3.5~4.5 hours following stimulation with CXCL2 as compared to the effect of CXCL2.

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Cell Cycle/DNA Damage

ROCK

ROCK

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1781882-72-1

415.32

C16H24Cl2N8O

>98% (HPLC)

In Vitro:?H2O 中的溶解度 : 50 mg/mL (120.39 mM; 超声助溶)

Cl.Cl.CCn1c(nc2cncc(CNC3CCNCC3)c12)-c1nonc1N

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(-20℃)

With Ice Pack

≥ 2 years