CAY10746

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CAY10746 是一种选择性 Rho 激酶 (ROCK) 抑制剂。CAY10746 对 ROCK I、ROCK II 具有抑制活性，IC50 值分别为 0.014 μM 和 0.003 μM。CAY10746 可用于糖尿病视网膜病变（DR）的研究。

CAY10746 is a selective Rho kinase (ROCK) inhibitor. CAY10746 has inhibitory activity for ROCK I, ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively. CAY10746 can be used for the research of diabetic retinopathy (DR).

Western Blot Analysis Cell Line:SH-SY5Y cells Concentration:0.1, 1 and 10 μM; 10 μM Incubation Time:2 h; 0.25, 1, 2 and 4 h Result:Inhibited the phosphorylation of MYPT1 but did not impact the MYPT1 expression in dose-dependence and time- dependence.Cell Proliferation Assay Cell Line:SH-SY5Y cells Concentration:1 μM Incubation Time:5 days Result:Significantly protected the cells from death. Cell Migration Assay Cell Line: HUVEC cells Concentration:1 μM Incubation Time:24 h, 36 h Result:Significantly reduced migrating cell numbers and significantly reduce the rate of wound healing at 24 h and 36 h.Apoptosis Analysis Cell Line:ex vivo DR model Concentration:1 μM Incubation Time:5 days Result: Significantly protected neuronal cells from death.

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Cell Cycle/DNA Damage

ROCK

ROCK

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2247240-76-0

457.48

C26H23N3O5

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 83.33 mg/mL (182.15 mM; 超声助溶 (<60°C)

CN(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)COc2ccc3c(c2)occc3=O)c1

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(-20℃)

With Ice Pack

≥ 2 years