PHGDH-IN-3

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PHGDH-IN-3 是一种磷酸甘油酸脱氢酶 (PHGDH) 抑制剂，具有口服活性。PHGDH-IN-3 抑制 PHGDH，IC50 值为 2.8 μM。PHGDH-IN-3 可用于癌症的研究。

PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor. PHGDH-IN-3 inhibits PHGDH with an IC50 value of 2.8 μM. PHGDH-IN-3 can be used for the research of cancer.

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Animal Model:Balb/c nude mice Dosage:12.5, 25, 50 mg/kg Administration:Intraperitoneal (i.p.); once daily for consecutive 31 days Result:Exhibited an in vivo anti-tumor effect and significantly delayed the tumor growth.Significantly abated the tumor weights of mice at 25 mg/ kg.

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Metabolic Enzyme/Protease

Dehydrogenase

Dehydrogenase

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2893778-31-7

495.55

C24H18FN3O4S2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (201.80 mM; 超声助溶 (<70°C)

N(C(=O)C1=CC=C(S(NC2=CC(C(C)=O)=CC=C2)(=O)=O)C=C1)C3=NC(=CS3)C4=CC(F)=CC=C4

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(-20℃)

With Ice Pack

≥ 2 years