QN523?

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

QN523 是一种具有类活性分子性质的新型支架，在 12 种癌细胞株中显示出强大的体外细胞毒性。QN523 诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)。QN523 可用于癌症的研究。

QN523 is a novel scaffold with agent-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 induces apoptosis and autophagy. QN523 can be used in research of cancer.

QN523 (72 h) has cytotoxicity with IC50 values ranging from 0.1 to 5.7 μM across 12 cell lines.QN523 (0.1 and 0.5 μM; 24 and 48 h; MIA PaCa-2 cells) arrests cell cycle at S phase and delays for pancreatic cancer cells to enter the G2-M phase. QN523 induces apoptosis and autophagy of MIA PaCa-2 Cells.Cell Cycle Analysis Cell Line:MIA PaCa-2 cells Concentration:0.1 and 0.5 μM Incubation Time:24 and 48 hours Result:Delayed for pancreatic cancer cells to enter the G2-M phase because of accumulation of cells in the S phase.Apoptosis Analysis Cell Line:MIA PaCa-2 cells Concentration:0.1 and 0.5 μM Incubation Time:24 and 48 hours Result: Increased the number of apoptotic cell in time- and dose-dependent manner.

QN523 (10 and 20 mg/kg; i.p.; daily, for 44 d) inhibits tumor growth in mice of pancreatic cancer xenografts.Animal Model:NOD/SCID mice of pancreatic cancer xenografts (6 weeks of age)Dosage:10 and 20 mg/kg Administration:Intraperitoneal administration; 1-9 days (10 mg/kg), 10-44 days (20 mg/kg) Result:Delayed growth of the tumors, and no systemic toxicity.

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Autophagy

Autophagy

Autophagy

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878581-60-3

250.26

C14H10N4O

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : ≥ 16.67 mg/mL (66.61 mM )

O=C(Nc1cccc2cccnc12)c1cnccn1

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(-20℃)

With Ice Pack

≥ 2 years