AZD5462

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AZD5462 是一种 RXFP1 调节剂，能够用于心力衰竭的研究。RXFP1 是人放松素同源受体，是 GPCR 家族的 1c 型蛋白，具有抗纤维化和抗炎特性。

AZD5462 is a RXFP1 modulator, can be used for heart failure research. RXFP1 is the cognate receptor for human relaxin, belongs to GPCR family 1c number with anti-fibrotic and anti-inflammatory properties.

AZD5462 (example 1) shows stimulatory activity on cAMP or cGMP production with EC50s of 17 nM and 50 nM, respectively.AZD5462 binds human plasma protein with fraction unbound (free) rate of 4.3%, and shows the stability with Clint values of 23 μL/min/mg (human licer microsomal), 4.8 μL/min/106 cells (human hepatocyte), and 11 μL/min/106 cells (rat hepatocyte).AZD5462 enhances phosphorylation of ERK with an EC50 value of 6.3 nM.

——

——

Others

Other Targets

RXFP receptor

——

——

2787501-83-9

544.65

C30H41FN2O6

>98% (HPLC)

——

C(NCC1(C)CCC1)(=O)[C@@H]2[C@H](NC(=O)C3=C(OC)C=C(F)C(O[C@H]4CC[C@](C(O)=O)(C)CC4)=C3)[C@@]5(C[C@]2(CC5)[H])[H]

——

(-20℃)

With Ice Pack

≥ 2 years