Picropodophyllin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Picropodophyllin (PPP) 是一种特异性 IGF-1R 抑制剂 (IC50: 1 nM)。鬼臼苦素特异性抑制 IGF1R 的活性并下调 IGF1R 的细胞表达，而不干扰其他生长因子受体的活性。

Picropodophyllin, also known as Picropodophyllotoxin, AXL1717 or PPP, is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis.

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AXL1717 | AXL-1717 | AXL 1717 | PPP | picropodophyllin

Others

Other Targets

IGF-1R

Cancer

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477-47-4

414.41

C22H22O8

>98% (HPLC)

DMSO : 50 mg/mL. 120.65 mM;

COc1cc(cc(c1OC)OC)[C@H]1[C@H]2[C@H](COC2=O)[C@H](c2cc3c(cc12)OCO3)O

(5R,5aS,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one

(-20℃)

With Ice Pack

≥ 2 years