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CRK12-IN-2
CAS No. 1990479-17-8
CRK12-IN-2 ( —— )
产品货号. M35735 CAS No. 1990479-17-8
CRK12-IN-2 (compound 2) 是 CRK12 的抑制剂。CRK12-IN-2 对 Trypanosoma congolense 和 Trypanosoma vivax 具有效能，其 EC50 值分别为 3.2 和 0.08 nM。CRK12-IN-2 可用于动物锥体虫病的研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1853 | 有现货 |
|
| 10MG | ￥2708 | 有现货 |
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| 25MG | ￥4166 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CRK12-IN-2
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CRK12-IN-2 (compound 2) 是 CRK12 的抑制剂。CRK12-IN-2 对 Trypanosoma congolense 和 Trypanosoma vivax 具有效能，其 EC50 值分别为 3.2 和 0.08 nM。CRK12-IN-2 可用于动物锥体虫病的研究。
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产品描述CRK12-IN-2 (compound 2) is an inhibitor of CRK12. CRK12-IN-2 shows potency against Trypanosoma congolense and Trypanosoma vivax with EC50 values of 3.2 and 0.08 nM. CRK12-IN-2 can be used for the research of animal trypanosomiasis.
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体外实验——
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体内实验CRK12-IN-2 (10 mg/kg; s.c. once daily for 4 days) effectively cures mice with T. congolense- and T. vivax-infection.Animal Model:Mice with T. congolense and T. vivax infection Dosage:10 mg/kg Administration: Subcutaneous injection; 10 mg/kg once daily; for 4 days Result:Fully cured both T. congolense- and T. vivax-infected mice for 4 days at a dose of 10 mg/kg.
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同义词——
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通路Microbiology/Virology
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靶点Parasite
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受体Parasite
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研究领域——
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适应症——
化学信息
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CAS Number1990479-17-8
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分子量529.67
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分子式C23H33F2N5O3S2
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纯度>98% (HPLC)
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溶解度——
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SMILESC(=O)(C=1SC(N[C@@H]2CC[C@@H](NS(CC(C)C)(=O)=O)CC2)=NC1N)C3=C(F)C=C(CN(C)C)C=C3F
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Smith A, et al. Repositioning of a Diaminothiazole Series Confirmed to Target the Cyclin-Dependent Kinase CRK12 for Use in the Treatment of African Animal Trypanosomiasis. J Med Chem. 2022 Apr 14;65(7):5606-5624.?
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