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Arterolane
CAS No. 664338-39-0
Arterolane ( OZ277 | RBx 11160 )
产品货号. M15532 CAS No. 664338-39-0
Arterolane (OZ277;RBx 11160) 是一种抗疟臭氧化物，用于治疗急性单纯性恶性疟疾。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1853 | 有现货 |
|
| 5MG | ￥2746 | 有现货 |
|
| 25MG | ￥9765 | 有现货 |
|
| 50MG | ￥12741 | 有现货 |
|
| 100MG | ￥19890 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥3021 | 有现货 |
|
生物学信息
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产品名称Arterolane
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Arterolane (OZ277;RBx 11160) 是一种抗疟臭氧化物，用于治疗急性单纯性恶性疟疾。
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产品描述Arterolane (OZ277;RBx 11160) is an antimalarial ozonide for treatment of acute uncomplicated falciparum malaria.Parasite Infection Phase 2 Discontinued.
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体外实验Arterolane (Trioxolane 7; OZ277; RBx-11160) is an antimalarial agent, with IC50s of both 1.1 nM (0.43 ng/mL) against P. falciparum Ro73 and W2, respectively. Arterolane also shows inhibitory activity against several other P. falciparums, with IC50s of 1.0, 1.6, 0.90, 0.91, 1.4, 1.5, 0.83, and 0.84 ng/mL for P. falciparum K1, Fc27, FVO, NF54, HB3, FCB1, ITG2-F6, and MAD20, respectively.
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体内实验——
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同义词OZ277 | RBx 11160
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通路Microbiology/Virology
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靶点Parasite
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受体Parasite
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研究领域Infection
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适应症Parasite Infection
化学信息
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CAS Number664338-39-0
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分子量392.54
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分子式C22H36N2O4
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纯度>98% (HPLC)
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溶解度DMSO : 100 mg/mL 254.76 mM
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SMILESO=C(NCC(C)(N)C)CC(CC1)CCC21OC3(OO2)C4CC5CC(C4)CC3C5
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化学全称N-(2-amino-2-methylpropyl)-2-{dispiro[adamantane-2,2'-[1,3,5]trioxolane-4',1''-cyclohexane]-4''-yl}acetamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Kreidenweiss A, et al. Antimicrob Agents Chemother. 2006 Apr;50(4):1535-7.
2. Vennerstrom JL, et al. Nature. 2004 Aug 19;430(7002):900-4.
3. Maerki S, et al. J Antimicrob Chemother. 2006 Jul;58(1):52-8.
4. Snyder C, et al. Exp Parasitol. 2007 Mar;115(3):296-300.
产品手册
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