Thiethylperazine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Thiethylperazine 是一种吩噻嗪衍生物，是一种口服有效的多巴胺 D2 受体和组胺 H1 受体拮抗剂。Thiethylperazine 也是一种选择性的 ABCC1 激活剂，可减少小鼠中的淀粉样 β (Aβ) 负荷。Thiethylperazine 具有止吐，抗精神病和抗菌作用。

Thiethylperazine, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine has anti-emetic, antipsychotic and antimicrobial effects.

Thiethylperazine can enhance the antibiotic (Vancomycin) activity at a concentration as low as 2 μg/mL. Thiethylperazine inhibits Vancomycin-sensitive E. faecalis ATCC 29212, Vancomycin-resistant E. faecalis ATCC 51299 and vancomycin-resistant E. faecalis (VREF) isolates with MIC values of 8 μg/mL, 16 μg/mL and 8 μg/mL, respectively.

Thiethylperazine (3 mg/kg; intramuscular injection; twice daily; for 30 days) significantly reduces Aβ42 levels in young APP/PS1 mice.Animal Model:Young Aβ precursor protein (APPswe) and mutant presenilin-1 (PS1) (APP/PS1) mice Dosage:3 mg/kg Administration:Intramuscular injection; twice daily; for 30 days Result:Significantly reduced Aβ42 levels in APP/PS1 mice.

——

GPCR/G Protein

Histamine Receptor

Histamine Receptor | Dopamine Receptor | Beta Amyloid | ABC

——

——

1420-55-9

399.62

C22H29N3S2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (250.24 mM; 超声助溶 )

CCSc1ccc2Sc3ccccc3N(CCCN3CCN(C)CC3)c2c1

——

(-20℃)

With Ice Pack

≥ 2 years