Levocetirizine Dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) 是第三代 peripheral H1-receptor 拮抗剂。Levocetirizine dihydrochloride 是一种抗组胺剂，是 Cetirizine 的 R 对映体。Levocetirizine dihydrochloride 对组胺 H1-受体的亲和力高于 (S)-Cetirizine，并且可用于研究变应性鼻炎和慢性特发性荨麻疹。

Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria.

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Levocetirizine (0.4 mg/kg; oral administration; male Sprague-Dawley rats) treatment shows that the Cmax, AUC0-t , AUC0-∞ and t1/2 are 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively in Sprague-Dawley rats.Animal Model:30 male Sprague-Dawley rats (8 weeks old; 200-250 g) Dosage:0.4 mg/kg Administration:Oral administration (Pharmacokinetic Analysis)Result:The Cmax, AUC0-t , AUC0-∞ and t1/2 were 0.34 μg/mL, 3.26 μg h/mL, 3.67 μg h/mL and 2.34 hours, respectively.

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GPCR/G Protein

Histamine Receptor

Histamine Receptor

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130018-87-0

461.81

C21H27Cl3N2O3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (216.54 mM; 超声助溶 ) H2O 中的溶解度 : 100 mg/mL (216.54 mM; 超声助溶)

O=C(O)COCCN1CCN([C@@H](C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1.Cl.Cl

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(-20℃)

With Ice Pack

≥ 2 years